Investigation of the Hβ Molecular Sieve Inactivation Caused by Reactants and Products and Improvement of Continuous Thiophene Acylation

In this paper, the factors leading to inactivation of molecular sieve are explored in batch thiophene (TH) acylation. The coexistence acetic anhydride (AC) as reactant and 2-acetylthiophene (2-ATH) product plays a key role accelerating inactivation, attributing 2-ATH polymerization. According simulation, when AC is not present, energy barrier polymerization can be reduced from 287.45 kJ/mol 85.87 kJ/mol. Then, process continuous TH acylation improved, which excessive (molar ratio). After optimizing molar ratio volume flowrate raw material, productivity catalyst reach 21.56 g/g, exceeds best previously studied (15.10 g/g). Subsequently, use carbon tetrachloride (CT) solvent further studied, hoping improve performance catalyst, significant advancement achieved, production capacity 45 g, conversion rate still high 96% after reaction carried out for 15,000 min.